High throughput screening

We have several key accomplishments in high throughput screening:

  • Established a manual screen for engineered Actinomycetes producing novel therapeutics, maintaining a throughput of 1000 clones per week with a hit rate of 1% (i.e. 1 NCE per 100 clones)
  • Identified a limitation in the high throughput screen for a biological insecticide, modified the screen to remove the limitation and delivered the first hit to be validated downstream in almost 10 years.
  • Automated a plate-based screen for testing novel antimicrobials against susceptible (MIC) and resistant (MIC50, MIC90) organisms including nosocomial clinical isolates.


Our consultants have a broad spectrum of experience in biotech and pharma:

  • Consulted with private equity firms. Provided market analyses and helped them understand the upsides and potential stumbling blocks in several biotech sectors.
  • Worked on several IP infringement cases. We have several patents pending and trade secrets and have written multiple IDMs. We have experience in IP harvesting.
  • We regularly conduct market analysis and understand the economic challenges in biotech particularly in the biochemical/biofuel space.

Metabolic Engineering / Genome editing

Our consultants have experience working with a wide range of organisms including gram-positive and gram negative bacteria, aerobes, anaerobes, yeast and fungi and mammalian cell lines. 

  • Technical expertise: CRISPR/Cas9, Oligo-Directed Mutagenesis, Timargeted Knock-out/Knock-in.
  • Engineered gram-positive aerobes for bioconversion of low rank coal to high value chemicals.
  • Delivered multiple engineered gram-negative species for bio-conversion of agricultural waste.
  • Delivered improved gram-positive anaerobes for lignocellulosic biofuel production.
  • Engineered stubborn soil bacteria to produce improved therapeutics (natural products).


We have helped clients maximize existing lab space, assisted in the move of several labs and designed and commissioned new lab spaces. 

  • We use LEAN principles to optimize workflows to save time and money.
  • We commissioned and certified several ISO-5 certified cleanrooms for Dow AgroSciences including a cGMP-compliant suite for High Throughput Screen and a high security vault/workspace for Strain Banking.
  • Experienced in validation including IQ/OQ/PQ

Plant design and operations

Our consultants can evaluate process flow diagrams, optimize unit ops and design field test quits.

  • Modified a Process Flow Diagram to include new unit ops for mitigation of bioburden in a biofuels manufacturing plant.
  • Created a portable microbiology and fermentation lab kit for taking accurate samples and acquiring relevant and timely data from field samples.